COGNITION AND AGE-RELATED SHIFTS IN THE MICROBIOME

We're delighted our work with colleagues at the University of East Anglia and the Quadram Institute has been published.

Using faecal microbiota transplants in mice, we have shown that giving the gut microbiota of old mice to young mice has measurable effects on the central nervous system. This work has important implications for understanding how aging and the microbiota influence neurological function, and may allow us to develop methods to target the microbiota to assist 'healthy aging'. Watch the video below to find out more about this exciting work!

Fecal transplants from aged mice impair cognitive function of younger mice from Research Square on Vimeo.

D’Amato, A., Di Cesare Mannelli, L., Lucarini, E. et al. Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients. Microbiome. 2020;doi.org/10.1186/s40168-020-00914-w.